Association between Periodontitis and Myocardial Infarction: Systematic Review and Meta-Analysis

Abstract The association between periodontitis and myocardial infarction remains unclear in the literature. Few studies have addressed periodontitis exposure as a predisposing factor for the development of myocardial infarction. Therefore, the present systematic review aims to analyze the association between periodontitis and myocardial infarction. This meta-analysis systematically searched MEDLINE, EMBASE, The Cochrane Controlled Trials Register, SCIELO, LILACS, CINAHL, Scopus, Web of Science and grey literature for studies estimating the association between periodontitis and myocardial infarction. Quality of evidence was assessed for all studies. The meta-analysis was conducted using random-effects models. Four of the six studies selected were included in the meta-analysis, including 1,035,703 subjects. The association between periodontitis and myocardial infarction was: RR: 5.99 (95% CI: 1.17-30.68), but with high heterogeneity (I2 = 100%; p <0.01). The results including only the highest quality articles, was lower: RR: 2.62 (95% CI: 1.47-4.70 3.83), but with lower heterogeneity (I2 = 85.5%; p < 0.01).The present systematic review with meta-analysis showed an association between periodontitis and acute myocardial infarction, but with a high level of heterogeneity.

Evaluation of the effect of locally administered amitriptyline gel as adjunct to local anesthetics in irreversible pulpitis pain.

BACKGROUND: Amitriptyline is one of the most common tricyclic antidepressants, which binds to pain sensory nerve fibers close to the sodium channel; hence, it could interact to some degree with receptors of local anesthetics. This study was designed to assess the additional analgesic effects of 2% Amitriptyline local gel administration in irreversible pulpitis pain of the molars. MATERIALS AND METHODS: This study was a randomized, double-blind clinical trial that was performed on 56 consented adult patients who did not receive enough analgesia after a lidocaine nerve block for their tooth pulpitis pain. Patients were treated with 0.2 ml of either 2% amitriptyline or placebo, which was directly injected into their mandibular molar pulp chamber after they had received two routine lidocaine injections. Patients were asked to score their pain as a mark on a 10-cm Visual Analogue Scale (VAS) at different timepoints: 0 (just before gel administration), 1, 3, 5, 7, and 9 minutes after the treatments. RESULTS: There was a 92.5% decrease in VAS scores of patients 9 minutes after amitriptyline administration compared to Time 0, while in the placebo group this difference was only 13.5%. Further, in the amitriptyline group, the VAS score at all timepoints was statistically different from Time 0 (P < 0.01). The overall pain reduction and its trend was significantly higher in the amitriptyline group compared with the placebo group (P < 0.001). CONCLUSION: Inter-pulp space administration of amitriptyline 2% gel for completing analgesia in irreversible pulpitis pain could be effective and useful as a conjunctive therapy to injections of local anesthetics.

Fístula odontogénica / Odontogenic cutaneous sinus tract

La fistula odontogénica es una patología que se expresa habitualmente como un nódulo crónico con episodios de superación intermitente localizado en cara. Su sospecha clínica permitirá su diagnóstico. La detección y el tratamiento de la causa que la originó resolverá el cuadro. Se presenta una paciente con fistula odontogénica de cinco meses de evolución al momento de la consulta dermatológica, en quien un correcto examen de su cavidad bucal permitió diagnosticar y tratar el absceso dentoalveolar que la había originado con resolución del cuadro

Dificuldades no diagnóstico diferencial de dores dentárias referidas à face: conduta clínica e consideraçöes sobre uma amostra / Difficulties in the differential diagnosis of the referred dental pain to face: considerations about a clinical sample

Säo apresentados e discutidos 5 relatos de casos clínicos de pacientes com dor referida craniofacial de causa dentária. Esses pacientes, embora atendidos inicialmente por dentistas foram encaminhados a especialistas para tratamento de desordem temporomandibular com o uso de placas de mordida ou a neurologistas para o tratamento de nevralgias ou de dor facial atípica, até serem definitivamente diagnosticados como portadores de patologia dentária. O diagnóstico final foi: periodontite apical aguda (2) e pulpite irreversível (3). A idade variou de 35 a 60 anos (média de 45) e a duraçäo da dor e dos tratamentos anteriores variou de 10 a 60 dias. Possivelmente o trauma oclusal foi um fator etiológico importante em 3 mulheres. Na quarta paciente a presença de um trauma mandibular e parestesia do lábio confundiram o diagnóstico de pulpite do 35. O único homem da amostra apresentava cárie subgengival do 43. É necessário conhecer os critérios para o diagnóstico diferencial e a aplicaçäo de métodos terapêuticos que sirvam de testes para ajudar no diagnóstico. Ter cautela antes de procedimentos invasivos, como extraçöes dentárias, que podem ser iatrogênicos ou fontes adicionais de dor, confundindo mais o quadro clínico e favorecendo a cronicidade em pacientes susceptíveis e, finalmente, estabelecer um protocolo de atendimento como estratégia para diagnóstico e controle da dor em casos considerados difíceis

Abscessos dentoalveolares agudos y su tratamiento con Hepar sulphur y Silicea terra / Acute dentoalveolar abscess and its treatment with Hepar sulphur and Silicea terra

Los abscesos dentoalveolares son una consecuencia de la infeccion pulpar. Se sabe que la enfermedad pulpar es una enfermedad muy comun en la consulta odontologica, practicamente un 70% de los pacientes que acuden a consulta, presentan este problema. La infeccion localizada en esta area es comun y frecuentemente se convierte en un foco a partir del cual la infeccion se disemina a otras partes del organismo. La Terapeutica Homeopatica es de gran ayuda, por las caracteristicas tan especificas de esta forma de tratamiento; ademas el uso de estos medicamentos, evita problemas como el "sensibilizar" y provocar trastornos alergicos, que incluso pueden llegar el choque anafilactico